Research
Behavioral research helps to answer important questions about optimal animal care and well-being, and improves our ability to meet the husbandry, social, and behavioral needs of the animals in our care. By analyzing behavior, researchers try to develop an understanding of animals’ learning processes, motivations, physical abilities, sensory adaptations and social structure. This information is then used to make decisions about managing animals. Working to understand orangutans’ sensory, cognitive, and physiological abilities can also be applied to conservation strategies, thereby benefiting orangutans in the wild as well.
Research using biomaterials is another important aspect, especially when such studies involve passive or voluntary collection of samples (e.g., urine, feces, hair, milk, recently even blood samples or blood pressure readings, etc.), or materials than can be collected opportunistically during scheduled anesthesia (e.g., body measurements taken during routine scheduled physical examination, collection of biological samples from apes not trained for voluntary collection, etc.).
Behavioral research helps to answer important questions about optimal animal care and well-being, and improves our ability to meet the husbandry, social, and behavioral needs of the animals in our care. By analyzing behavior, researchers try to develop an understanding of animals’ learning processes, motivations, physical abilities, sensory adaptations and social structure. This information is then used to make decisions about managing animals. Working to understand orangutans’ sensory, cognitive, and physiological abilities can also be applied to conservation strategies, thereby benefiting orangutans in the wild as well.
Research using biomaterials is another important aspect, especially when such studies involve passive or voluntary collection of samples (e.g., urine, feces, hair, milk, recently even blood samples or blood pressure readings, etc.), or materials than can be collected opportunistically during scheduled anesthesia (e.g., body measurements taken during routine scheduled physical examination, collection of biological samples from apes not trained for voluntary collection, etc.).
The SSP Research/Biomaterials Request Approval Process
Research and biomaterials proposals submitted to the Orangutan SSP are reviewed by the SSP's Steering Committee and Advisors. Proposals are judged on significance, application completeness and content, study design, logistics, and relevance to the Orangutan SSP program. The reviewers recommend that a proposal be ENDORSED (high priority, good science, advances objectives of the SSP, strongly encourage zoos to participate); APPROVED (moderate priority, good science, zoos should participate if they can); REJECTED (questionable science or value or other concerns); or that More Information Is Needed. The application form intentionally mirrors the Standardized Research Proposal form developed by the AZA’s Research and Technology Committee. Applicants will be notified of the Steering Committee’s majority decision within 6 weeks after submission of your completed application.
Click here to download the Orangutan SSP Research/Biomaterials Application.
Click here for Grant Funding information and Application
Why Submit Your Research Proposal to the SSP?
Some studies can be accomplished by collecting data on just a few individuals, and in those cases, researchers may choose to work directly with their local zoo for access to orangutans. Many research projects, however, benefit from the inclusion of data from a large number of individuals. In those cases especially, working through the Orangutan SSP can be of significant benefit to the scientist. While SSP endorsement does not compel individual zoos to participate, it does encourage such participation; and for many zoos, SSP endorsement is a prerequisite to acceptance through their own internal research approval process. Having a letter of support from the SSP can also be beneficial in obtaining outside funding for research projects.
Current Supported Projects
Each of the following research projects has been reviewed and approved by the Steering Committee, and SSP-member zoos are encouraged to participate in these studies. Projects are updated on an annual basis for progress and status.
The Orangutan SSP supports the Great Ape Heart Project, an IMLS-funded project to design an innovative and coordinated national program to investigate ape cardiovascular disease (CVD) and establish uniform, state of the art cardiac diagnosis, treatment and prevention strategies for great ape CVD. Click here to learn more about the Great Ape Heart Project.
Orangutan fecal microbiome analysis: Stephanie McCain, DVM, Dipl ACZM (Birmingham Zoo), Richard Sim, DVM, Dipl ACZM (Oregon Zoo), and Casey Morrow, PhD (University of Alabama, Birmingham). An inordinate number of zoo housed orangutans have either chronic constipation or chronic diarrhea, with an underlying cause rarely identified. (Nancy Lung, personnal comm.) Many zoos must manage one or both of these conditions, regardless of diet fed, illustrating the need to have a better understanding of orangutan GI health. The goal of this study is to understand how the gut microbe community structure correlates with and can influence the health and behavior of zoo-housed orangutans. In order to accomplish this goal, we plan to perform microbiome analysis on fecal samples from all individual orangutans housed in the United States and evaluate these results against diet, fecal consistency, and pedigree. (Approved January 2020)
Chronological Investigation of Flanging in Male Orangutans Faye Harwell (PhD Candidate at Boston University) & Cheryl Knott PhD (Boston University & Gunung Palung Orangutan Project). Male bimaturism, exhibited in orangutans, is a rare phenomenon among primates and mammals in general. Both the duration of this process and the order of changes in testosterone levels, skeletal growth, body size, and cheek pads are unknown. We aim to examine the process of flanging in a chronological manner to establish the duration of this developmental process and determine the sequence of morphological and hormonal changes that take place. In particular, we will measure testosterone levels, length of the flanges, and length of the forearm (as a proxy for skeletal growth) as well as collect any weight measurements taken on an individual while participating in the study. The findings from this study will provide orangutan caretakers with information regarding the variability, duration, and extent of flanging. Read the full project proposal and information on participation here. Please contact Faye Harwell or Cheryl Knott with any questions or inquiries about participation. (Approved June 2019)
The Giant Panda Management as a Model for the Malayan Tiger and Bornean Orang Utan Management in Malaysia: Rohana Jani, PhD (University of Malaya), Noor Hashida Hashim, PhD (University of Malaya), Mohd. Tajuddin Abdullah, PhD (University Malaysia Terengganu) and Dennis Ten Choon Yung (University of Malaya/PERHILITAN). The Giant Panda has been placed under the Endangered red list status since 1990.Its status has been down listed from Endangered to Vulnerable in 2016. The conservation works on the Giant Panda is indeed a successful conservation effort. While both IUCN Red List of Threatened Species status for the Malayan Tiger and Bornean Orang Utan have been elevated from Endangered to Critically Endangered in 2015 and 2014. Currently, the Giant Panda conservation model is proven as the successful wildlife conservation model; an in-depth adaption is needed to enable such model to be applied to other threatened species to ensure the model benefited to the targeted species. We seek to understand the Giant Panda conservation management and the possibility that the captive Giant Panda conservation management model may contribute to the conservation management of Malayan Tiger and Bornean Orang Utan. The survey exercise will be distributed to animal captive facilities. The outcome of the study is potentially contributed to the country zoo management and captive wildlife management. (Approved Mar 2019)
Differential Gene Expression in healthy and diseased eyeballs of orangutans: Juan Olvido Perea-García (National University of Singapore) .The advent of sequencing technologies represents a great opportunity to inspect the genetic bases of pathologies. Great apes, like humans, suffer from chronic conditions that impair their ability to see, such as cataracts. In this project, we aim to identify genes associated with healthy and diseased individuals by inspecting their expression in eyeballs. This will give us insight about the bases of pathologies, as well as the ways in which bodies respond to said pathologies. If we can identify gene variants that are consistently associated with ocular pathologies, zoos can also make better informed decisions to let individuals breed based on their genotype. Because great apes and humans are so closely related, the data can also be used to learn more about the way in which our eyes evolved. (Approved Dec 2018)
A survey of the prevalence and perceived efficacy of biofloors in great ape exhibits within AZA zoos: Jill Moyse, Curator of Primates, Lincoln Park Zoo. This research project will survey AZA institutions that house great apes to investigate the type of biofloor, if any, the animals have access to throughout the day and overnight. The survey will look at the prevalence of bio floors and the decisions made to provide bio floors from a management perspective. By comparing the attitudes and experiences of institutions that have biofloors to those that do not, we hope to elucidate what the motivations are for institutions to install them as well as what the barriers are to including biofloors in the design of new buildings or the refurbishment of existing exhibits. It is expected that cost and concerns over hygiene will represent common barriers, but we also anticipate that responses from intuitions that have biofloors in their exhibit will dispel such concerns. (Approved Dec 2018)
Retrospective Classification and Management Assessment of Canine Fractures in Captive Managed Populations of Great Apes: Jill Moyse, Curator of Primates, Lincoln Park Zoo. At this time, it is unknown how many individual great apes in the captive population have broken, fractured and or cracked canine teeth. As several approaches for treatment or repair are possible, it is not known which of these injuries correlate best with the available management options. Long-term effects of no treatment are not predictable. The retrospective project will survey the captive managed great ape population to assess the occurrence of injuries and what treatment was provided to the animal. Zoo veterinarians will be surveyed to document any great apes in their collection that have any incidents of breakage, cracked or fracture of the canine teeth in the last 10 years. We anticipate majority to full participation from the SSP institutions that house great apes and will be able to compile an inventory of all animals that currently have canine fractures, breaks or cracks, the treatment they received and if any common risk factors are associated with the canine fractures. With this information, it is anticipated that prospective guidance of treatment options can be provided to institutions, veterinarians and the great ape SSP when animals present a fracture, break or cracked canine. (Approved Nov 2018)
Investigating the Composition of the Milk of Apes: Dr. Mike Power PhD, Mike Maslanka and Erin Stromberg, Smithsonian National Zoo. This is a continuation of ongoing research. The objective is to obtain longitudinal milk samples from apes (bonobos, chimpanzees, gorillas, orangutans, and gibbons), from shortly after birth until the female is no longer lactating, in order to further characterize the nutritional content of ape milk, continue investigating the milk microbiota of non-human primates, and learn more about the potential role of bioactive molecules in mother’s milk to regulate offspring physiology and metabolism (among other questions). Additional milk samples from females whose milk has not previously been collected are important to document the extent to which there are species-specific patterns and the extent of variation between females. To date, samples have been obtained from 3 orangutans and 7 lowland gorillas. We aim to receive samples from 10-12 individuals from each ape species in order to be able to fully characterize variation between females. Results of this work are shared widely for the benefit of zoos worldwide. Samples are available for collaborative research projects. (Approved Oct 2018)
Orangutan Growth and Development and Reproductive Strategies: Alexandra Kralick (PI, PhD student at University of Pennsylvania), Janet Monge PhD (Penn Museum and University of Pennsylvania), and Meredith Bastian PhD (Smithsonian National Zoo). Adult male orangutans exist as either flanged, with full secondary sexual characteristics, or unflanged. The processes that mediate this strategy are poorly understood. This project aims to provide inslight by examining the relationship between skeletal development and the development of these sexual characteristics with zoo data on orangutan age, sex, flanging status, and utilizing radiographic images. Participation will aid our understanding of orangutan reproductive strategies, and illuminate ways in which captivity affects orangutan growth and development. Contact Alexandra Kralick or Meredith Bastian here. (Approved Dec 2017)
Pubescence in Captive Orangutans (Pongo abelii and P. pygmaeus): Anneke Moresco, DVM, PhD, Internal Research Manager Denver Zoo and Advisory Board Member AZA Reproductive Management Center, Cindy Cossaboon, BSc. Orangutan SSP steering committee member and primate keeper, Denver Zoo, Joe Smith, DVM, Orangutan SSP Veterinary Advisor and Director of Animal Programs Fort Wayne Children's Zoo and Nancy Lung, VMD, MS, Orangutan SSP Veterinary Advisor. In order to properly manage primates in captivity, it is important to determine when females and males become fertile if they are housed together. This knowledge is necessary to make management decisions such as when to start administering contraception if these would be matings that the SSP does not deem valuable, such as in the case of related animals. In many species mating and sexual behavior can be used as a proxy for onset of fertility. In orangutans however, this behavior is not a reliable indicator of sexual maturity as sexual behavior can take place in a variety of social contexts, not just for reproduction. The main goals of this project are to collect information to improve understanding of reproductive onset in orangutans, thereby fine-tuning reproductive management of young females. Read the full project proposal and information on participation here. Contact Anneke Moesco or Cindy Cossaboon here. (Approved Aug 2016)
Development of a database of fetal ultrasound measurements for the creation of orangutan-specific (Pongo spp.) growth curves and determination of parturition dates: Current data is lacking in species specific fetal growth curves and gestation lengths for orangutans. Dr. Brittany Rizzo, along with Connie Warner, Dr. Joe Smith, and Dr. Ric Berlinski, is compiling existing fetal ultrasound and birth date information as well as gathering future information in the hopes of creating more accurate and species-specific fetal growth curves for orangutans. Data of this nature can benefit institutions via improved planning for their training and social structure changes. Additionally, in cases of animals that have had previous difficult births or emergency cesarean sections, accurate determination of gestational age for scheduling future cesarean sections can reduce the risk of complications for both the dam and the infant. Please click here for project description and information on participation; click here for contact information. (Approved Sep 2014)
The Effects of a Low-Starch Diet on Behavior and Insulin Resistance Syndrome in Several Primate Species: Dr. Elena Less is also working with specific zoos to test the effect of a low-starch biscuit on health. Under the hypothesis that some zoo primates may have diet-induced insulin resistance syndrome, the project aims to examine the effect of a low-starch diet on serum parameters associated with insulin resistance syndrome in several primate species. Information on this study can be found here; click here for contact information. (Approved June 2012)
Important Diseases of Rehabilitant Orangutans: Clinical Aspects of Epidemiology, Diagnosis and Treatment: The Central Kalimantan Orangutan Reintroduction Project of the Borneo Orangutan Survival Foundation at Nyaru Menteng (BOS-NM) holds the largest population of captive orangutans in the world, and associated health and veterinary records over a number of years. Analysis of the data contained within the clinic records, along with some investigative procedures, could fill in a number of knowledge-gaps, and contribute to the health and welfare of captive orangutans not only within BOS-NM, but across the world. Rosalie Dench is working to summarize retrospectively the incidence of orangutan diseases at BOS-NM and establish normal reference ranges for body weight and blood results for the population, which can act as a baseline for analyses, as well as evaluate current diagnostic methods in more detail for several diseases of significance. Click here for more detail on this project; click here for contact information. (Approved Sep 2012)
Captive Orangutan Dentition Emergence: Felicity Oram is investigating tooth emergence in orangutans. The specific primary objective is to provide a comprehensive updated tooth emergence chart for both species. The need is for more consistent and specific age assignment to better serve husbandry and rehabilitation of orphans and to help build stronger cases for enforcement of existing laws that protect these endangered species in range countries. Additionally, this will provide zoos with a useful updated resource of baseline normals for tooth emergence. Since orangutans are a slow-growing long-lived species of a semi-solitary nature many zoos hold only a few individuals so the benefit of accumulated knowledge in a simple format will be useful for husbandry and veterinary care of zoo residents. Please review the project proposal and the report form for more information; click here for contact information. (Approved June 2013)
Great Ape Neuroscience Project: The goal of the Great Ape Neuroscience Project is to investigate the neurobiological basis of variation that distinguishes great apes from other primates, defines each great ape species as unique, and helps us to better understand humans’ place in nature. The Great Ape Neuroscience Project originated as an extension of the Great Ape Aging Project (funded by the National Institute on Aging of the National Institutes of Health). The Great Ape Aging Project was conceived of as a means of adding scientific value to elderly apes in captivity. Medical scientists studying the causes of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases expressed interest in studies of brain and behavior in great apes to determine whether or not the same neurodegenerative processes occurred in them as in afflicted humans. The convergence of these interests and needs led to the development of the Great Ape Aging Project in 1997. This project seeks whole fixed brains from great apes (and other primates) at necropsy. Several documents describe the project and its requirements: Great Ape Neuroscience Project 2011 Progress Report; Project description and Contact information; TAG project approval letter; Detailed brain collection and submission instructions. Bibliography of articles related to this project. (Approved Sep 2012)
Genetic and phenotypic characterization of cystic fibrosis airway disease in non-human primates: Gram negative rod infection, bronchiectasis and chronic sinus drainage characterize the respiratory syndrome that is present in approximately 20-40% of captive orangutans. Despite response to pulmonary therapies used in Cystic Fibrosis (CF), respiratory disease in this population leads to extensive morbidity and early mortality. Although originally theorized to be related to environmental conditions/exposures, a recent evaluation of predisposing factors demonstrated that diseased animals were more often genetically related to animals with respiratory disease (93%) than to healthy animals (54%). While chimpanzees are synonymous with the non-human primate most closely genetically related to humans, orangutans share 97% of their genome with humans. Based on this genetic homology, and the similarities to respiratory signs and symptoms seen in CF pulmonary disease, we hypothesized that the phenotype in orangutans may be caused by mutations in the CF gene. We performed ciliary ultrastructure examination and DNA analysis of blood on a 30 year-old orangutan with chronic sinusitis, bronchiectasis and S. aureus and P. aeruginosa infection. We demonstrated the presence of normal cilia and 3 CF gene variants. DNA analysis from a healthy orangutan from the same zoo showed no CF gene variants. The overall objective of this research is to establish if mutations in the CF gene are associated with chronic sinopulmonary disease in orangutans. Please click here for the detailed project description and contact information; the submission form for specimens/medical records is included here. (Approved Mar 2014)
The Orang-utan Conservation Genetics Project: The principal aim of this project is to conduct a range of genetic studies, using samples from orangutans housed internationally in zoos and rehabilitation centres, to facilitate conservation of these endangered apes. The collective aim of these studies is to facilitate the most informed captive management programme for any species worldwide, with genetic data for every individual in the breeding programme. These data would be used in collaboration with the World Association of Zoos and Aquariums – and, in particular, with the International Studbook Keeper – to heighten and maintain the long-term genetic diversity of orangutans held in zoos. Data arising from several studies may also assist with in-situ conservation efforts, facilitating the reintroduction of displaced orangutans from rehabilitation centres. This project is led by Dr Graham L Banes of the University of Wisconsin-Madison. (Renewed May 2017)
Research and biomaterials proposals submitted to the Orangutan SSP are reviewed by the SSP's Steering Committee and Advisors. Proposals are judged on significance, application completeness and content, study design, logistics, and relevance to the Orangutan SSP program. The reviewers recommend that a proposal be ENDORSED (high priority, good science, advances objectives of the SSP, strongly encourage zoos to participate); APPROVED (moderate priority, good science, zoos should participate if they can); REJECTED (questionable science or value or other concerns); or that More Information Is Needed. The application form intentionally mirrors the Standardized Research Proposal form developed by the AZA’s Research and Technology Committee. Applicants will be notified of the Steering Committee’s majority decision within 6 weeks after submission of your completed application.
Click here to download the Orangutan SSP Research/Biomaterials Application.
Click here for Grant Funding information and Application
Why Submit Your Research Proposal to the SSP?
Some studies can be accomplished by collecting data on just a few individuals, and in those cases, researchers may choose to work directly with their local zoo for access to orangutans. Many research projects, however, benefit from the inclusion of data from a large number of individuals. In those cases especially, working through the Orangutan SSP can be of significant benefit to the scientist. While SSP endorsement does not compel individual zoos to participate, it does encourage such participation; and for many zoos, SSP endorsement is a prerequisite to acceptance through their own internal research approval process. Having a letter of support from the SSP can also be beneficial in obtaining outside funding for research projects.
Current Supported Projects
Each of the following research projects has been reviewed and approved by the Steering Committee, and SSP-member zoos are encouraged to participate in these studies. Projects are updated on an annual basis for progress and status.
The Orangutan SSP supports the Great Ape Heart Project, an IMLS-funded project to design an innovative and coordinated national program to investigate ape cardiovascular disease (CVD) and establish uniform, state of the art cardiac diagnosis, treatment and prevention strategies for great ape CVD. Click here to learn more about the Great Ape Heart Project.
Orangutan fecal microbiome analysis: Stephanie McCain, DVM, Dipl ACZM (Birmingham Zoo), Richard Sim, DVM, Dipl ACZM (Oregon Zoo), and Casey Morrow, PhD (University of Alabama, Birmingham). An inordinate number of zoo housed orangutans have either chronic constipation or chronic diarrhea, with an underlying cause rarely identified. (Nancy Lung, personnal comm.) Many zoos must manage one or both of these conditions, regardless of diet fed, illustrating the need to have a better understanding of orangutan GI health. The goal of this study is to understand how the gut microbe community structure correlates with and can influence the health and behavior of zoo-housed orangutans. In order to accomplish this goal, we plan to perform microbiome analysis on fecal samples from all individual orangutans housed in the United States and evaluate these results against diet, fecal consistency, and pedigree. (Approved January 2020)
Chronological Investigation of Flanging in Male Orangutans Faye Harwell (PhD Candidate at Boston University) & Cheryl Knott PhD (Boston University & Gunung Palung Orangutan Project). Male bimaturism, exhibited in orangutans, is a rare phenomenon among primates and mammals in general. Both the duration of this process and the order of changes in testosterone levels, skeletal growth, body size, and cheek pads are unknown. We aim to examine the process of flanging in a chronological manner to establish the duration of this developmental process and determine the sequence of morphological and hormonal changes that take place. In particular, we will measure testosterone levels, length of the flanges, and length of the forearm (as a proxy for skeletal growth) as well as collect any weight measurements taken on an individual while participating in the study. The findings from this study will provide orangutan caretakers with information regarding the variability, duration, and extent of flanging. Read the full project proposal and information on participation here. Please contact Faye Harwell or Cheryl Knott with any questions or inquiries about participation. (Approved June 2019)
The Giant Panda Management as a Model for the Malayan Tiger and Bornean Orang Utan Management in Malaysia: Rohana Jani, PhD (University of Malaya), Noor Hashida Hashim, PhD (University of Malaya), Mohd. Tajuddin Abdullah, PhD (University Malaysia Terengganu) and Dennis Ten Choon Yung (University of Malaya/PERHILITAN). The Giant Panda has been placed under the Endangered red list status since 1990.Its status has been down listed from Endangered to Vulnerable in 2016. The conservation works on the Giant Panda is indeed a successful conservation effort. While both IUCN Red List of Threatened Species status for the Malayan Tiger and Bornean Orang Utan have been elevated from Endangered to Critically Endangered in 2015 and 2014. Currently, the Giant Panda conservation model is proven as the successful wildlife conservation model; an in-depth adaption is needed to enable such model to be applied to other threatened species to ensure the model benefited to the targeted species. We seek to understand the Giant Panda conservation management and the possibility that the captive Giant Panda conservation management model may contribute to the conservation management of Malayan Tiger and Bornean Orang Utan. The survey exercise will be distributed to animal captive facilities. The outcome of the study is potentially contributed to the country zoo management and captive wildlife management. (Approved Mar 2019)
Differential Gene Expression in healthy and diseased eyeballs of orangutans: Juan Olvido Perea-García (National University of Singapore) .The advent of sequencing technologies represents a great opportunity to inspect the genetic bases of pathologies. Great apes, like humans, suffer from chronic conditions that impair their ability to see, such as cataracts. In this project, we aim to identify genes associated with healthy and diseased individuals by inspecting their expression in eyeballs. This will give us insight about the bases of pathologies, as well as the ways in which bodies respond to said pathologies. If we can identify gene variants that are consistently associated with ocular pathologies, zoos can also make better informed decisions to let individuals breed based on their genotype. Because great apes and humans are so closely related, the data can also be used to learn more about the way in which our eyes evolved. (Approved Dec 2018)
A survey of the prevalence and perceived efficacy of biofloors in great ape exhibits within AZA zoos: Jill Moyse, Curator of Primates, Lincoln Park Zoo. This research project will survey AZA institutions that house great apes to investigate the type of biofloor, if any, the animals have access to throughout the day and overnight. The survey will look at the prevalence of bio floors and the decisions made to provide bio floors from a management perspective. By comparing the attitudes and experiences of institutions that have biofloors to those that do not, we hope to elucidate what the motivations are for institutions to install them as well as what the barriers are to including biofloors in the design of new buildings or the refurbishment of existing exhibits. It is expected that cost and concerns over hygiene will represent common barriers, but we also anticipate that responses from intuitions that have biofloors in their exhibit will dispel such concerns. (Approved Dec 2018)
Retrospective Classification and Management Assessment of Canine Fractures in Captive Managed Populations of Great Apes: Jill Moyse, Curator of Primates, Lincoln Park Zoo. At this time, it is unknown how many individual great apes in the captive population have broken, fractured and or cracked canine teeth. As several approaches for treatment or repair are possible, it is not known which of these injuries correlate best with the available management options. Long-term effects of no treatment are not predictable. The retrospective project will survey the captive managed great ape population to assess the occurrence of injuries and what treatment was provided to the animal. Zoo veterinarians will be surveyed to document any great apes in their collection that have any incidents of breakage, cracked or fracture of the canine teeth in the last 10 years. We anticipate majority to full participation from the SSP institutions that house great apes and will be able to compile an inventory of all animals that currently have canine fractures, breaks or cracks, the treatment they received and if any common risk factors are associated with the canine fractures. With this information, it is anticipated that prospective guidance of treatment options can be provided to institutions, veterinarians and the great ape SSP when animals present a fracture, break or cracked canine. (Approved Nov 2018)
Investigating the Composition of the Milk of Apes: Dr. Mike Power PhD, Mike Maslanka and Erin Stromberg, Smithsonian National Zoo. This is a continuation of ongoing research. The objective is to obtain longitudinal milk samples from apes (bonobos, chimpanzees, gorillas, orangutans, and gibbons), from shortly after birth until the female is no longer lactating, in order to further characterize the nutritional content of ape milk, continue investigating the milk microbiota of non-human primates, and learn more about the potential role of bioactive molecules in mother’s milk to regulate offspring physiology and metabolism (among other questions). Additional milk samples from females whose milk has not previously been collected are important to document the extent to which there are species-specific patterns and the extent of variation between females. To date, samples have been obtained from 3 orangutans and 7 lowland gorillas. We aim to receive samples from 10-12 individuals from each ape species in order to be able to fully characterize variation between females. Results of this work are shared widely for the benefit of zoos worldwide. Samples are available for collaborative research projects. (Approved Oct 2018)
Orangutan Growth and Development and Reproductive Strategies: Alexandra Kralick (PI, PhD student at University of Pennsylvania), Janet Monge PhD (Penn Museum and University of Pennsylvania), and Meredith Bastian PhD (Smithsonian National Zoo). Adult male orangutans exist as either flanged, with full secondary sexual characteristics, or unflanged. The processes that mediate this strategy are poorly understood. This project aims to provide inslight by examining the relationship between skeletal development and the development of these sexual characteristics with zoo data on orangutan age, sex, flanging status, and utilizing radiographic images. Participation will aid our understanding of orangutan reproductive strategies, and illuminate ways in which captivity affects orangutan growth and development. Contact Alexandra Kralick or Meredith Bastian here. (Approved Dec 2017)
Pubescence in Captive Orangutans (Pongo abelii and P. pygmaeus): Anneke Moresco, DVM, PhD, Internal Research Manager Denver Zoo and Advisory Board Member AZA Reproductive Management Center, Cindy Cossaboon, BSc. Orangutan SSP steering committee member and primate keeper, Denver Zoo, Joe Smith, DVM, Orangutan SSP Veterinary Advisor and Director of Animal Programs Fort Wayne Children's Zoo and Nancy Lung, VMD, MS, Orangutan SSP Veterinary Advisor. In order to properly manage primates in captivity, it is important to determine when females and males become fertile if they are housed together. This knowledge is necessary to make management decisions such as when to start administering contraception if these would be matings that the SSP does not deem valuable, such as in the case of related animals. In many species mating and sexual behavior can be used as a proxy for onset of fertility. In orangutans however, this behavior is not a reliable indicator of sexual maturity as sexual behavior can take place in a variety of social contexts, not just for reproduction. The main goals of this project are to collect information to improve understanding of reproductive onset in orangutans, thereby fine-tuning reproductive management of young females. Read the full project proposal and information on participation here. Contact Anneke Moesco or Cindy Cossaboon here. (Approved Aug 2016)
Development of a database of fetal ultrasound measurements for the creation of orangutan-specific (Pongo spp.) growth curves and determination of parturition dates: Current data is lacking in species specific fetal growth curves and gestation lengths for orangutans. Dr. Brittany Rizzo, along with Connie Warner, Dr. Joe Smith, and Dr. Ric Berlinski, is compiling existing fetal ultrasound and birth date information as well as gathering future information in the hopes of creating more accurate and species-specific fetal growth curves for orangutans. Data of this nature can benefit institutions via improved planning for their training and social structure changes. Additionally, in cases of animals that have had previous difficult births or emergency cesarean sections, accurate determination of gestational age for scheduling future cesarean sections can reduce the risk of complications for both the dam and the infant. Please click here for project description and information on participation; click here for contact information. (Approved Sep 2014)
The Effects of a Low-Starch Diet on Behavior and Insulin Resistance Syndrome in Several Primate Species: Dr. Elena Less is also working with specific zoos to test the effect of a low-starch biscuit on health. Under the hypothesis that some zoo primates may have diet-induced insulin resistance syndrome, the project aims to examine the effect of a low-starch diet on serum parameters associated with insulin resistance syndrome in several primate species. Information on this study can be found here; click here for contact information. (Approved June 2012)
Important Diseases of Rehabilitant Orangutans: Clinical Aspects of Epidemiology, Diagnosis and Treatment: The Central Kalimantan Orangutan Reintroduction Project of the Borneo Orangutan Survival Foundation at Nyaru Menteng (BOS-NM) holds the largest population of captive orangutans in the world, and associated health and veterinary records over a number of years. Analysis of the data contained within the clinic records, along with some investigative procedures, could fill in a number of knowledge-gaps, and contribute to the health and welfare of captive orangutans not only within BOS-NM, but across the world. Rosalie Dench is working to summarize retrospectively the incidence of orangutan diseases at BOS-NM and establish normal reference ranges for body weight and blood results for the population, which can act as a baseline for analyses, as well as evaluate current diagnostic methods in more detail for several diseases of significance. Click here for more detail on this project; click here for contact information. (Approved Sep 2012)
Captive Orangutan Dentition Emergence: Felicity Oram is investigating tooth emergence in orangutans. The specific primary objective is to provide a comprehensive updated tooth emergence chart for both species. The need is for more consistent and specific age assignment to better serve husbandry and rehabilitation of orphans and to help build stronger cases for enforcement of existing laws that protect these endangered species in range countries. Additionally, this will provide zoos with a useful updated resource of baseline normals for tooth emergence. Since orangutans are a slow-growing long-lived species of a semi-solitary nature many zoos hold only a few individuals so the benefit of accumulated knowledge in a simple format will be useful for husbandry and veterinary care of zoo residents. Please review the project proposal and the report form for more information; click here for contact information. (Approved June 2013)
Great Ape Neuroscience Project: The goal of the Great Ape Neuroscience Project is to investigate the neurobiological basis of variation that distinguishes great apes from other primates, defines each great ape species as unique, and helps us to better understand humans’ place in nature. The Great Ape Neuroscience Project originated as an extension of the Great Ape Aging Project (funded by the National Institute on Aging of the National Institutes of Health). The Great Ape Aging Project was conceived of as a means of adding scientific value to elderly apes in captivity. Medical scientists studying the causes of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases expressed interest in studies of brain and behavior in great apes to determine whether or not the same neurodegenerative processes occurred in them as in afflicted humans. The convergence of these interests and needs led to the development of the Great Ape Aging Project in 1997. This project seeks whole fixed brains from great apes (and other primates) at necropsy. Several documents describe the project and its requirements: Great Ape Neuroscience Project 2011 Progress Report; Project description and Contact information; TAG project approval letter; Detailed brain collection and submission instructions. Bibliography of articles related to this project. (Approved Sep 2012)
Genetic and phenotypic characterization of cystic fibrosis airway disease in non-human primates: Gram negative rod infection, bronchiectasis and chronic sinus drainage characterize the respiratory syndrome that is present in approximately 20-40% of captive orangutans. Despite response to pulmonary therapies used in Cystic Fibrosis (CF), respiratory disease in this population leads to extensive morbidity and early mortality. Although originally theorized to be related to environmental conditions/exposures, a recent evaluation of predisposing factors demonstrated that diseased animals were more often genetically related to animals with respiratory disease (93%) than to healthy animals (54%). While chimpanzees are synonymous with the non-human primate most closely genetically related to humans, orangutans share 97% of their genome with humans. Based on this genetic homology, and the similarities to respiratory signs and symptoms seen in CF pulmonary disease, we hypothesized that the phenotype in orangutans may be caused by mutations in the CF gene. We performed ciliary ultrastructure examination and DNA analysis of blood on a 30 year-old orangutan with chronic sinusitis, bronchiectasis and S. aureus and P. aeruginosa infection. We demonstrated the presence of normal cilia and 3 CF gene variants. DNA analysis from a healthy orangutan from the same zoo showed no CF gene variants. The overall objective of this research is to establish if mutations in the CF gene are associated with chronic sinopulmonary disease in orangutans. Please click here for the detailed project description and contact information; the submission form for specimens/medical records is included here. (Approved Mar 2014)
The Orang-utan Conservation Genetics Project: The principal aim of this project is to conduct a range of genetic studies, using samples from orangutans housed internationally in zoos and rehabilitation centres, to facilitate conservation of these endangered apes. The collective aim of these studies is to facilitate the most informed captive management programme for any species worldwide, with genetic data for every individual in the breeding programme. These data would be used in collaboration with the World Association of Zoos and Aquariums – and, in particular, with the International Studbook Keeper – to heighten and maintain the long-term genetic diversity of orangutans held in zoos. Data arising from several studies may also assist with in-situ conservation efforts, facilitating the reintroduction of displaced orangutans from rehabilitation centres. This project is led by Dr Graham L Banes of the University of Wisconsin-Madison. (Renewed May 2017)
Completed Projects
A search for chemical signals in orang-utans: Male orangutan cheek pads are frequently hypothesised to have arisen through sexual selection, influenced by female preference or by male-male competition. However, their potential role in attracting females is not yet fully understood – nor is their potential role in suppressing development in unflanged males. In this preliminary study, Dr Graham L Banes, Professor Tom E Goodwin (Hendrix College) and Melanie Bond (National Zoo, retired) are using use solid phase dynamic extraction (SPDE) gas chromatography mass spectrometry (GC-MS) to identify volatile organic compounds that may emanate from orang-utan cheek pads. The research was featured on the PBS documentary, “Sex in the Wild: Orangutans”.
Variation in Vocal Repertoires of Wild and Captive Orangutans: Although most research on great ape vocalizations has been on chimpanzees, recent field research has produced a catalogue of a wide variety of orangutan vocalizations. Geographic variation in orangutan vocalizations has been identified both within call type and in the presence of certain vocalizations among wild populations. This study aims to catalogue vocal recordings collected across AZA zoo-housed orangutan collections and compare these to those previously documented in the wild. We are especially interested in the context of vocalizations, in novel vocalizations, and in the extent to which keepers can identify the meaning of the vocalizations they hear and record. Please click here for project description and information on participation; click here for contact information.
Respiratory Disease in the North American Captive Orangutan Population: Megan K. Fox of the Los Angeles Zoo and Botanical Gardens and Graduate Student, Evolutionary Anthropology at California State University, Fullerton. This project aims to identify some of the factors that influence the presence of respiratory disease in the North American captive orangutan population. Understanding if there are species differences in the prevalence of disease between the Sumatran and Bornean orangutan, between the sexes, between certain age classes, and between individuals at various developmental stages will provide valuable information and assist in the management of these species. This project also aims to identify other factors that may influence the onset of disease, such as weight, body condition, family history, rearing history, stress events, and environmental factors. Additionally, this project will provide information on the types of symptoms most commonly experienced that will also contribute to the possible early treatment and diagnoses of respiratory disease in captive orangutans. Identifying the risk factors involved will greatly enhance the ability for zoological institutions to act preemptively to treat disease which can ultimately assist in the overall care, management, and survivability of the individuals involved and hence the population as a whole. Contact Megan Fox here.
Insulin Resistance in Old World Primates: Dr. Elena Less of the Cleveland Metroparks Zoo is studying biomarkers of insulin resistance over time in several primate species, orangutans being the representative for apes. Dr. Less’s goal is to determine the effect of increasing age/time spent in captivity on insulin, glucose, cholesterol and triglycerides in banked serum samples from orangutans, Hamadryas baboons, mandrills, ring-tailed lemurs, and red ruffed lemurs. Click here for project description and information on participation; click here for contact information. PENDING ANALYSIS
Important Diseases of Rehabilitant Orangutans: Clinical Aspects of Epidemiology, Diagnosis and Treatment: The Central Kalimantan Orangutan Reintroduction Project of the Borneo Orangutan Survival Foundation at Nyaru Menteng (BOS-NM) holds the largest population of captive orangutans in the world, and associated health and veterinary records over a number of years. Analysis of the data contained within the clinic records, along with some investigative procedures, could fill in a number of knowledge-gaps, and contribute to the health and welfare of captive orangutans not only within BOS-NM, but across the world. Rosalie Dench is working to summarize retrospectively the incidence of orangutan diseases at BOS-NM and establish normal reference ranges for body weight and blood results for the population, which can act as a baseline for analyses, as well as evaluate current diagnostic methods in more detail for several diseases of significance. Click here for more detail on this project; click here for contact information. Work on TB testing, Air Sacculitis Risk Factors and normal ranges for orangutan bodyweight and haematology parameters has already been completed; please contact Rosalie Dench for further information.
Thyroid histology in orangutans with non‐congenital thyroid dysfunction, led by Dr. Sandra M. McLachlan of Cedars‐Sinai Medical Center in Los Angeles. This project investigated thyroid dysfunction in great apes by examining thyroid hormone levels and TSH in all nonhuman great ape genera including adults, adolescents, and infants, and establishing a thyroid hormone and TSH database in orangutans, gorillas, chimpanzees, and bonobos (447 individuals). The most striking differences found between these 4 great ape genera were greatly reduced FT4 and FT3 levels in orangutans and gorillas, and elevated TSH levels in gorillas, compared with chimpanzees and bonobos. In addition, autoantibodies to Tg and TPO were detectable in only 2.6% of adult great apes, significantly lower than the approximately 10% in humans. No great apes with thyroid autoantibodies exhibited thyroid dysfunction and neither thyroid autoantibodies nor thyroid lymphocytic infiltration were present in hypothyroid great apes. The researchers also concluded that hypothyroidism in the closest surviving human relatives may involve dietary components including goitrogens but is unrelated to thyroid autoimmunity. Click here to read the Endocrinology article detailing this work.
Cataloging Blood Types for SSP Populations of Great Apes, led by Kathryn Gamble and Jill Moyse, Lincoln Park Zoo. In humans and domestic mammals, blood typing plays an important role in providing excellent medical care in critical care situations. It has been repeatedly demonstrated that humans and great apes have conserved identities within the standard blood typing categories of A-B-O and D(Rh factor). Development of simple table-top laboratory techniques to identify these most basic of blood groups in human patients may be applied to similar benefit in the great ape species. Click here to read the Zoo Biology article detailing this work.
Jaw Gape in Primates, William Hylander, Duke Lemur Center. This project is part of a broad-based comparative study on feeding adaptations in anthropoid primates. There may be important morphological differences in terms of jaw mechanics between orangutans from Borneo as compared to those from Sumatra. If these supposed differences prove to be significant, this will indicate important morphological differences in terms of orangutan jaw-muscle architecture. This in turn is likely related to differences in feeding ecology. This project is now complete and data are being prepared for publication; results will be posted here when available.
Factors influencing male orang-utan reproductive success, Dr. Graham L. Banes, Max Planck Institute for Evolutionary Anthropology. Male orang-utans exhibit one of two physical forms: dominant males develop large 'cheek pads' on their faces, while socially subordinate males do not. The purpose of these ornaments has long been poorly understood. Though cheek pads are hypothesised to make dominant males more attractive to females, thus resulting in greater reproductive success, males without them are also known to have fathered offspring in the wild and in zoos — so why develop cheek pads if you can father offspring without them? A team led by Dr Graham L Banes of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, performed paternity testing of orang-utans at Camp Leakey in Tanjung Puting National Park, Indonesia, to see if the dominant male — Kusasi — was more reproductively successful than his rivals. Not only did Kusasi father almost all of the offspring born during his period of dominance, other males typically only achieved conceptions at the beginning and end of Kusasi's reign, when the dominance hierarchy was potentially unstable. The authors concluded that male bimaturism is likely to be an evolutionarily stable strategy, in which non-cheek-padded males simply bide their time until periods of rank instability. The methods for genetic analyses used in this research, which was published in September 2015 in the journal Behavioral Ecology and Sociobiology, were developed using faecal samples from the Los Angeles Zoo and Botanical Gardens, CA, St Paul's Como Zoo and Conservatory, MN, and Henry Vilas Zoo in Madison, WI. The study was featured by The Washington Post, Discovery News and The Daily Mail, and profiled on Serious Science. Preliminary findings were originally presented at the 9th Annual Orangutan SSP Husbandry Workshop at the Los Angeles Zoo and Botanical Gardens in August 2013.
Cytokine Production and Urinary Excretion in the Orangutan: Drs. Lyle Moldawer and Erin Vogel are investigating the hypothesis that a high degree of endotoxin-responsiveness and cytokine production is shared by orangutans and humans. Their study seeks (1) to determine cross-reactivity among orangutan cytokines and human immunoassay reagents, (2) to determine ex vivo cytokine production to bacterial endotoxin by whole blood obtained from orangutans, and (3) to measure hemopexin and other acute phase reactant proteins that bind endotoxin (LBP, BPI) in the plasma of orangutan. Click here for project description and information on participation; click here for contact information.
A retrospective study of cardiovascular disease in captive orangutans (Pongo sp.): This study, conducted by Drs. Amanda Marino and Lauren Howard, will provide a systematic review of the current cases of cardiovascular disease diagnosed in captive orangutans pre-mortem. This project will provide an overview of the unique attributes of orangutan physiology and how it may affect cardiac function, as well as how heart disease in orangutans differs from other great apes. Additionally, this paper will act as a source of information on the clinical signs of disease, risk factors of disease, and the current thoughts on how to manage cardiac disease in orangutans. This paper will advance our knowledge of cardiovascular disease and improve our ability to diagnose and treat captive orangutans. Please click here for project details, information on participation, and contact information.
A search for chemical signals in orang-utans: Male orangutan cheek pads are frequently hypothesised to have arisen through sexual selection, influenced by female preference or by male-male competition. However, their potential role in attracting females is not yet fully understood – nor is their potential role in suppressing development in unflanged males. In this preliminary study, Dr Graham L Banes, Professor Tom E Goodwin (Hendrix College) and Melanie Bond (National Zoo, retired) are using use solid phase dynamic extraction (SPDE) gas chromatography mass spectrometry (GC-MS) to identify volatile organic compounds that may emanate from orang-utan cheek pads. The research was featured on the PBS documentary, “Sex in the Wild: Orangutans”.
Variation in Vocal Repertoires of Wild and Captive Orangutans: Although most research on great ape vocalizations has been on chimpanzees, recent field research has produced a catalogue of a wide variety of orangutan vocalizations. Geographic variation in orangutan vocalizations has been identified both within call type and in the presence of certain vocalizations among wild populations. This study aims to catalogue vocal recordings collected across AZA zoo-housed orangutan collections and compare these to those previously documented in the wild. We are especially interested in the context of vocalizations, in novel vocalizations, and in the extent to which keepers can identify the meaning of the vocalizations they hear and record. Please click here for project description and information on participation; click here for contact information.
Respiratory Disease in the North American Captive Orangutan Population: Megan K. Fox of the Los Angeles Zoo and Botanical Gardens and Graduate Student, Evolutionary Anthropology at California State University, Fullerton. This project aims to identify some of the factors that influence the presence of respiratory disease in the North American captive orangutan population. Understanding if there are species differences in the prevalence of disease between the Sumatran and Bornean orangutan, between the sexes, between certain age classes, and between individuals at various developmental stages will provide valuable information and assist in the management of these species. This project also aims to identify other factors that may influence the onset of disease, such as weight, body condition, family history, rearing history, stress events, and environmental factors. Additionally, this project will provide information on the types of symptoms most commonly experienced that will also contribute to the possible early treatment and diagnoses of respiratory disease in captive orangutans. Identifying the risk factors involved will greatly enhance the ability for zoological institutions to act preemptively to treat disease which can ultimately assist in the overall care, management, and survivability of the individuals involved and hence the population as a whole. Contact Megan Fox here.
Insulin Resistance in Old World Primates: Dr. Elena Less of the Cleveland Metroparks Zoo is studying biomarkers of insulin resistance over time in several primate species, orangutans being the representative for apes. Dr. Less’s goal is to determine the effect of increasing age/time spent in captivity on insulin, glucose, cholesterol and triglycerides in banked serum samples from orangutans, Hamadryas baboons, mandrills, ring-tailed lemurs, and red ruffed lemurs. Click here for project description and information on participation; click here for contact information. PENDING ANALYSIS
Important Diseases of Rehabilitant Orangutans: Clinical Aspects of Epidemiology, Diagnosis and Treatment: The Central Kalimantan Orangutan Reintroduction Project of the Borneo Orangutan Survival Foundation at Nyaru Menteng (BOS-NM) holds the largest population of captive orangutans in the world, and associated health and veterinary records over a number of years. Analysis of the data contained within the clinic records, along with some investigative procedures, could fill in a number of knowledge-gaps, and contribute to the health and welfare of captive orangutans not only within BOS-NM, but across the world. Rosalie Dench is working to summarize retrospectively the incidence of orangutan diseases at BOS-NM and establish normal reference ranges for body weight and blood results for the population, which can act as a baseline for analyses, as well as evaluate current diagnostic methods in more detail for several diseases of significance. Click here for more detail on this project; click here for contact information. Work on TB testing, Air Sacculitis Risk Factors and normal ranges for orangutan bodyweight and haematology parameters has already been completed; please contact Rosalie Dench for further information.
Thyroid histology in orangutans with non‐congenital thyroid dysfunction, led by Dr. Sandra M. McLachlan of Cedars‐Sinai Medical Center in Los Angeles. This project investigated thyroid dysfunction in great apes by examining thyroid hormone levels and TSH in all nonhuman great ape genera including adults, adolescents, and infants, and establishing a thyroid hormone and TSH database in orangutans, gorillas, chimpanzees, and bonobos (447 individuals). The most striking differences found between these 4 great ape genera were greatly reduced FT4 and FT3 levels in orangutans and gorillas, and elevated TSH levels in gorillas, compared with chimpanzees and bonobos. In addition, autoantibodies to Tg and TPO were detectable in only 2.6% of adult great apes, significantly lower than the approximately 10% in humans. No great apes with thyroid autoantibodies exhibited thyroid dysfunction and neither thyroid autoantibodies nor thyroid lymphocytic infiltration were present in hypothyroid great apes. The researchers also concluded that hypothyroidism in the closest surviving human relatives may involve dietary components including goitrogens but is unrelated to thyroid autoimmunity. Click here to read the Endocrinology article detailing this work.
Cataloging Blood Types for SSP Populations of Great Apes, led by Kathryn Gamble and Jill Moyse, Lincoln Park Zoo. In humans and domestic mammals, blood typing plays an important role in providing excellent medical care in critical care situations. It has been repeatedly demonstrated that humans and great apes have conserved identities within the standard blood typing categories of A-B-O and D(Rh factor). Development of simple table-top laboratory techniques to identify these most basic of blood groups in human patients may be applied to similar benefit in the great ape species. Click here to read the Zoo Biology article detailing this work.
Jaw Gape in Primates, William Hylander, Duke Lemur Center. This project is part of a broad-based comparative study on feeding adaptations in anthropoid primates. There may be important morphological differences in terms of jaw mechanics between orangutans from Borneo as compared to those from Sumatra. If these supposed differences prove to be significant, this will indicate important morphological differences in terms of orangutan jaw-muscle architecture. This in turn is likely related to differences in feeding ecology. This project is now complete and data are being prepared for publication; results will be posted here when available.
Factors influencing male orang-utan reproductive success, Dr. Graham L. Banes, Max Planck Institute for Evolutionary Anthropology. Male orang-utans exhibit one of two physical forms: dominant males develop large 'cheek pads' on their faces, while socially subordinate males do not. The purpose of these ornaments has long been poorly understood. Though cheek pads are hypothesised to make dominant males more attractive to females, thus resulting in greater reproductive success, males without them are also known to have fathered offspring in the wild and in zoos — so why develop cheek pads if you can father offspring without them? A team led by Dr Graham L Banes of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, performed paternity testing of orang-utans at Camp Leakey in Tanjung Puting National Park, Indonesia, to see if the dominant male — Kusasi — was more reproductively successful than his rivals. Not only did Kusasi father almost all of the offspring born during his period of dominance, other males typically only achieved conceptions at the beginning and end of Kusasi's reign, when the dominance hierarchy was potentially unstable. The authors concluded that male bimaturism is likely to be an evolutionarily stable strategy, in which non-cheek-padded males simply bide their time until periods of rank instability. The methods for genetic analyses used in this research, which was published in September 2015 in the journal Behavioral Ecology and Sociobiology, were developed using faecal samples from the Los Angeles Zoo and Botanical Gardens, CA, St Paul's Como Zoo and Conservatory, MN, and Henry Vilas Zoo in Madison, WI. The study was featured by The Washington Post, Discovery News and The Daily Mail, and profiled on Serious Science. Preliminary findings were originally presented at the 9th Annual Orangutan SSP Husbandry Workshop at the Los Angeles Zoo and Botanical Gardens in August 2013.
Cytokine Production and Urinary Excretion in the Orangutan: Drs. Lyle Moldawer and Erin Vogel are investigating the hypothesis that a high degree of endotoxin-responsiveness and cytokine production is shared by orangutans and humans. Their study seeks (1) to determine cross-reactivity among orangutan cytokines and human immunoassay reagents, (2) to determine ex vivo cytokine production to bacterial endotoxin by whole blood obtained from orangutans, and (3) to measure hemopexin and other acute phase reactant proteins that bind endotoxin (LBP, BPI) in the plasma of orangutan. Click here for project description and information on participation; click here for contact information.
A retrospective study of cardiovascular disease in captive orangutans (Pongo sp.): This study, conducted by Drs. Amanda Marino and Lauren Howard, will provide a systematic review of the current cases of cardiovascular disease diagnosed in captive orangutans pre-mortem. This project will provide an overview of the unique attributes of orangutan physiology and how it may affect cardiac function, as well as how heart disease in orangutans differs from other great apes. Additionally, this paper will act as a source of information on the clinical signs of disease, risk factors of disease, and the current thoughts on how to manage cardiac disease in orangutans. This paper will advance our knowledge of cardiovascular disease and improve our ability to diagnose and treat captive orangutans. Please click here for project details, information on participation, and contact information.